USB flash drives have been used in the past to attack computer systems. One of the most popular worms that was spread via removable devices was the Conficker worm which infected millions of computer systems. Some – but not all – security programs protect the computer system from attacks carried out from USB flash drives that are connected to the computer systems.
USB Guardian is a free security program for the Windows operating system that can add the protection from threats that use removable devices as their attack vector. The program basically runs silently in the system background after installation. It will automatically scan USB flash drives that are connected to the computer system.
USB Guardian isolates autorun directives on the removable device. This blocks any program from being executed after connecting the device to the PC.
The security software then scans the autorun.inf file on the flash drive to find out if it references additional files that might be dangerous to the computer system. The executable files that are found will also be locked automatically.

The user is free to use the USB flash drive from that point on as usual. The locked files on the other hand are not accessible since they are still locked by USB Guardian. The user can use the program interface to unlock files in case they are harmless. It is furthermore possible to use the interface to delete the locked files and to configure program options like enabling the autostart of USB Guardian.
USB Guardian is compatible with 32-bit and 64-bit editions of the Microsoft Windows operating system. The program tries to install a toolbar during installation. This toolbar is not required to run the program. The download of USB Guardian is provided at the developer’s website.
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Using a software for removing viruses is always best thing for novice users. USB guardian is a good product, I’ve tried it 1-2 times. But, what I suggest is if someone really want to learn tricks and twicks of Operating system then try to remove them without any software installation.
http://www.tutkiun.com/2010/03/solutions-to-usb-pen-drive-problems.html