If you use Firebug and visit Gmail you receive a message “Firebug is known to make Google Mail slow unless it is configured correctly” which was not known by me. Google suggests to disable Firebug for the Google domain completely which should not be a huge problem normally.
To do this you simply right-click the green Firebug icon in the status bar and select “Disable Firebug for mail.google.com”. Another option offered by Google would be to disable certain features of Firebug while visiting Gmail. Those are the Show XMLHttpRequests and Disable Network Monitoring options.
I was not able to verify any slowdowns with Firebug and was not able to verify any speed ups after disabling Firebug when visiting Gmail. I suppose some users can experience them and this is why I thought it would be nice to post this information.
To disable the options in Firebug you do the following:
1.Click the green or red icon in the bottom right corner of the browser window to open Firebug.
2.Click the Console tab.
3.Select Options.
4.Uncheck Show XMLHttpRequests.
5.Click the Net tab.
6.Select Options.
7.Check Disable Network Monitoring.

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I’m using FF3 and firebug 1.2.0b3 and often see slowness (sometimes even crashing firefox) when firebug is enabled.
I haven’t tried the method listed above, but I find it easier just to keep firebug disabled when I’m not actively using it.